About
StackTrial is written by an M.Sc. in biochemistry and molecular and cellular biology. It applies a simple scientific method: every grade is based on published human studies, and every reference links by DOI to the original article.
How the grades work
Each supplement is graded separately for each goal, on human evidence:
- AStrong evidence
- BModerate evidence
- CWeak evidence
- C→DWeak to very weak
- DVery weak / contested
Human trials are the standard. Animal and mechanistic studies are reported for context, but they do not earn a grade on their own.
Null and negative trials are cited alongside positive ones. Where the cited evidence has been criticised on methodological grounds, the critique is cited too. Collagen is an example: its skin entry lists the meta-analyses reporting a benefit and, next to them, a paper arguing those meta-analyses are unreliable.
Coverage
The database currently covers 27 compounds across six goals. Some compound and goal pairs have not been reviewed yet; these are labelled not assessed, which is different from no evidence (reviewed, and nothing found in humans).
Educational use only
StackTrial is an educational tool, not a medical device, and it does not give medical advice. It summarises published research; it does not diagnose, recommend doses, or assess the safety of your combination. Talk to a doctor or pharmacist before starting, stopping or changing any supplement.
Found an error?
Please report it. Each supplement in your results has a Report an error link at the bottom of its card. Use it for a wrong grade, a broken link, or a citation that does not say what we claim it says.
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